Medicine

Evolving ASO therapies coming from development to application

.Contending passions.R.S., M.S., H.G. and also A.A.R. are actually planners of the 1M1M effort. H.G. and also A.A.R. are board of directors members and also R.S., M.S. as well as A.A.R. are actually participants of the medical consultatory committee of N1C. A.A.R. discloses job through LUMC, which possesses licenses on exon-skipping technology, a number of which has actually been licensed to BioMarin and also subsequently sublicensed to Sarepta. As co-inventor of several of these licenses, A.A.R. was entitled to a share of aristocracies. A.A.R. further reveals acting as ad hoc consultant for PTC Therapeutics, Sarepta Therapies, Regenxbio, Dyne Therapeutics, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. In the past 5 years, A.A.R. additionally executed impromptu speaking with for Alpha Anomeric. A.A.R. additionally discloses subscription of the scientific boards of advisers of Eisai, Hybridize Rehabs, Silence Rehabs, Sarepta Rehabs, Sapreme and also Mitorx. Before 5 years, A.A.R. was actually likewise a medical advisory board member for ProQR. Reimbursement for A.A.R. u00e2 s consulting and advising activities is paid to LUMC. In the past 5 years, LUMC additionally got speaker honoraria from PTC Therapies, Alnylam Netherlands, Italfarmaco and Pfizer as well as moneying for agreement research from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Venture financing is actually gotten from Sarepta Rehabs as well as Entrada by means of unrestricted grants. H.G. has nothing at all to divulge in connection with the subjects covered in this document. Before 5 years, he has likewise gotten working as a consultant honoraria coming from UCB. M.S. obtained consultancy gratuity from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa over the last 5 years, all unrelated to today composition. R.S. has absolutely nothing to disclose in connection with the subject matters dealt with within this manuscript. She has acquired audio speaker and/or consultancy gratuity or even funding additions coming from Abbvie, Bial, STADA as well as Everpharma in the past 5 years.

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